Phosphatidylinositol 3-kinase tor2 (tor2) Recombinant Protein | tor2 recombinant protein

Recombinant Schizosaccharomyces pombe Phosphatidylinositol 3-kinase tor2 (tor2), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Phosphatidylinositol 3-kinase tor2 (tor2); Recombinant Schizosaccharomyces pombe Phosphatidylinositol 3-kinase tor2 (tor2); partial; tor2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2,337

• Species: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 162312164
• NCBI GeneID: 2540720
• NCBI Accession #: NP_595359.2
• NCBI GenBank Nucleotide #: NM_001021266.3
• UniProt Accession #: Q9Y7K2; O94507
• Molecular Weight: 266,379 Da
• NCBI Official Full Name: phosphatidylinositol kinase Tor2
• NCBI Official Symbol: tor2
• NCBI Protein Information: phosphatidylinositol kinase Tor2
• UniProt Protein Name: Serine/threonine-protein kinase tor2
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: tor2

Uniprot Description

Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC1 controls the switch between cell proliferation and differentiation by sensing nutrient availability. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression (PubMed:17121544, PubMed:17179073, PubMed:17261596). In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) psk1 at 'Thr-392' and 'Thr-415', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6. Also catalyzes the nutrient-dependent phosphorylation of sck1 and sck2 (PubMed:20144990, PubMed:22976295). TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2 (PubMed:17046992).