Troponin I, fast skeletal muscle (TNNI2) Recombinant Protein | TNNI2 recombinant protein

Recombinant Human Troponin I, fast skeletal muscle (TNNI2)

Cat. Num. AAA960360

• Gene Names: TNNI2; DA2B; FSSV; fsTnI; AMCD2B
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Troponin I; fast skeletal muscle (TNNI2); Recombinant Human Troponin I; TNNI2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-182, Full length protein
• Sequence: GDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES
• Sequence Length: 181

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TNNI2 recombinant protein

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 224967057
• NCBI GeneID: 7136
• NCBI Accession #: NP_001139301.1
• NCBI GenBank Nucleotide #: NM_001145829.1
• UniProt Accession #: P48788; A6NIV8; A6NJU5
• Molecular Weight: 21,355 Da
• NCBI Official Full Name: troponin I, fast skeletal muscle isoform 1
• NCBI Official Synonym Full Names: troponin I2, fast skeletal type
• NCBI Official Symbol: TNNI2
• NCBI Official Synonym Symbols: DA2B; FSSV; fsTnI; AMCD2B
• NCBI Protein Information: troponin I, fast skeletal muscle
• UniProt Protein Name: Troponin I, fast skeletal muscle
• Protein Family: Troponin
• UniProt Gene Name: TNNI2

NCBI Description

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.