Mouse tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 ELISA Kit | TNKS2 elisa kit
Mouse Tankyrase-2, TNKS2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
Protein type: Transferase; Nuclear envelope; EC 2.4.2.30
Cellular Component: Golgi apparatus; chromosome, telomeric region; pericentriolar material; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; chromosome; nucleus
Molecular Function: transferase activity; transferase activity, transferring glycosyl groups; enzyme binding; metal ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: protein amino acid ADP-ribosylation; protein polyubiquitination; Wnt receptor signaling pathway; multicellular organism growth; regulation of multicellular organism growth; telomere maintenance
Research Articles on TNKS2
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Product Notes
The Mouse TNKS2 tnks2 (Catalog #AAA9316129) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316129 ELISA Kit recognizes Mouse TNKS2. It is sometimes possible for the material contained within the vial of "tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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