Tankyrase-1 (Tnks) Recombinant Protein | Tnks recombinant protein
Recombinant Mouse Tankyrase-1 (Tnks) , partial
NCBI and Uniprot Product Information
Uniprot Description
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity ().
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Product Notes
The Tnks tnks (Catalog #AAA1458481) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1105-1310. partial. The amino acid sequence is listed below: APEDKEYQSV EEEMQSTIRE HRDGGNAGGI FNRYNVIRIQ KVVNKKLRER FCHRQKEVSE ENHNHHNERM LFHGSPFINA IIHKGFDERH AYIGGMFGAG IYFAENSSKS NQYVYGIGGG TGCPTHKDRS CYICHRQMLF CRVTLGKSFL QFSTMKMAHA PPGHHSVIGR PSVNGLAYAE YVIYRGEQAY PEYLITYQIM KPEAPS . It is sometimes possible for the material contained within the vial of "Tankyrase-1 (Tnks), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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