TNF-R-II / TNFR2 Blocking Peptide | Tnfrsf1b blocking peptide
TNF-R-II / TNFR2 Immunizing Peptide
NCBI and Uniprot Product Information
Uniprot Description
TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: axon; cell soma; integral to membrane; integral to plasma membrane; lipid raft; membrane; nucleus; perinuclear region of cytoplasm
Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding
Biological Process: cell proliferation; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; immune response; inflammatory response; multicellular organismal development; negative regulation of inflammatory response; positive regulation of MAPKKK cascade; positive regulation of membrane protein ectodomain proteolysis; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; RNA destabilization
Research Articles on Tnfrsf1b
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Product Notes
The Tnfrsf1b tnfrsf1b (Catalog #AAA427405) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The TNF-R-II / TNFR2 Immunizing Peptide reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: KHFCNKTSDT VCAD. It is sometimes possible for the material contained within the vial of "TNF-R-II / TNFR2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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