TNFRSF19 / TROY recombinant protein
Recombinant Mouse TNFRSF19 / TROY Protein (His tag)
Gene Names
Tnfrsf19; TAJ; Troy; TRADE; AL023044; AW123854; TAJ-ALPHA
Purity
> 95 % as determined by SDS-PAGE
Synonyms
TNFRSF19 / TROY; Recombinant Mouse TNFRSF19 / TROY Protein (His tag); AL023044; AW123854; TAJ; TAJ-ALPHA; TRADE; Troy; TNFRSF19 / TROY recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
416
Application Notes
The recombinant mouse TNFRSF19 consists of 152 amino acids and has a predicted molecular mass of 17 kDa. Due to glycosylation, the apparent molecular mass of rmTNFRSF19 is approximately 25-32 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Glu 30
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for TNFRSF19 / TROY recombinant protein
Background: Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the ductal epithelium of the prostate and parotid glands. TNFRSF19/TROY expression is detected in some adenocarcinoma cell lines that arise from this tissue. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. TNFRSF19/TROY is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19/TROY was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins (C/EBP). TNFRSF19 signals activation of the Jnk pathway and induces cell death. Overexpression of TNFRSF19 also signals NFB activation, comparable and similar to that by p75NGFR. TNFRSF19/TROY is capable of activating key signaling pathways of the TNF receptor family, and its predominant expression patterns suggest that it plays a role in the growth and regulation of epithelial tissues.
Description: A DNA sequence encoding the extracellular domain (Met 1-Leu 170) of mouse TNFRSF19 (NP_001157627.1) was fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the extracellular domain (Met 1-Leu 170) of mouse TNFRSF19 (NP_001157627.1) was fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,471 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 19
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 19
NCBI Official Symbol
Tnfrsf19
NCBI Official Synonym Symbols
TAJ; Troy; TRADE; AL023044; AW123854; TAJ-ALPHA
NCBI Protein Information
tumor necrosis factor receptor superfamily member 19
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 19
UniProt Gene Name
Tnfrsf19
UniProt Synonym Gene Names
Taj; Troy
Uniprot Description
TNFRSF19: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 14|14 D1
Cellular Component: plasma membrane
Molecular Function: receptor activity
Biological Process: hair follicle development; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade
Research Articles on TNFRSF19 / TROY
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Product Notes
The TNFRSF19 / TROY tnfrsf19 (Catalog #AAA2547137) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse TNFRSF19 consists of 152 amino acids and has a predicted molecular mass of 17 kDa. Due to glycosylation, the apparent molecular mass of rmTNFRSF19 is approximately 25-32 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the TNFRSF19 / TROY tnfrsf19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF19 / TROY, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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