Human Tumor necrosis factor receptor superfamily member 10A ELISA Kit | TNFRSF10A elisa kit
Human Tumor necrosis factor receptor superfamily member 10A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Uniprot Description
TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: cell surface; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: death receptor activity; protease binding; protein binding; transcription factor binding; tumor necrosis factor receptor activity
Biological Process: caspase activation; cell surface receptor linked signal transduction; immune response; inflammatory response; leukocyte migration; multicellular organismal development; negative regulation of caspase activity; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; signal transduction
Research Articles on TNFRSF10A
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Product Notes
The Human TNFRSF10A tnfrsf10a (Catalog #AAA9428623) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9428623 ELISA Kit recognizes Human TNFRSF10A. It is sometimes possible for the material contained within the vial of "Tumor necrosis factor receptor superfamily member 10A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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