TM55B Blocking Peptide | TMEM55B blocking peptide

TM55B Antibody (C-term) Blocking Peptide

• Gene Names: TMEM55B; C14orf9
• Synonyms: TM55B; TM55B Antibody (C-term) Blocking Peptide; Type 1 phosphatidylinositol 4;5-bisphosphate 4-phosphatase; Type 1 PtdIns-4;5-P2 4-Ptase; PtdIns-4;5-P2 4-Ptase I; Transmembrane protein 55B; TMEM55B; C14orf9; TMEM55B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of TM55B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 277

• Cellular Location: Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein
• Tissue Location: Ubiquitous..
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TMEM55B blocking peptide

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate.

NCBI and Uniprot Product Information

• NCBI GI #: 33112243
• NCBI GeneID: 90809
• UniProt Accession #: Q86T03; Q86U09; Q8WUC0; Q9BU67; Q9NSU8; B2RA35
• Molecular Weight: 15,191 Da
• NCBI Official Full Name: Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
• NCBI Official Synonym Full Names: transmembrane protein 55B
• NCBI Official Symbol: TMEM55B
• NCBI Official Synonym Symbols: C14orf9
• NCBI Protein Information: type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
• UniProt Protein Name: Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
• Protein Family: Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
• UniProt Gene Name: TMEM55B
• UniProt Synonym Gene Names: C14orf9; Type 1 PtdIns-4,5-P2 4-Ptase
• UniProt Entry Name: TM55B_HUMAN

NCBI Description

TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

Uniprot Description

TMEM55B: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Hydrolase; Membrane protein, integral; EC 3.1.3.78

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: late endosome membrane; lysosomal membrane

Biological Process: phosphoinositide dephosphorylation