Human Transmembrane protein 126A ELISA Kit | TMEM126A elisa kit

Human Transmembrane protein 126A ELISA Kit

Cat. Num. AAA764784

• Gene Names: TMEM126A; OPA7
• Reactivity: Human
• Synonyms: Transmembrane protein 126A; Human Transmembrane protein 126A ELISA Kit; TMEM126A; TMEM126A elisa kit

• Reactivity: Human
• Sequence Length: 195

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 0.156-10ng/ml
• Sensitivity: 0.094ng/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Testing Data

Typical Standard Curve

Related Product Information for TMEM126A elisa kit

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human TMEM126A antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human TMEM126A antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and wash with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human TMEM126A amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration ofHuman TMEM126A can be calculated.

NCBI and Uniprot Product Information

• NCBI GI #: 119595508
• NCBI GeneID: 84233
• Molecular Weight: 13,844 Da
• NCBI Official Full Name: transmembrane protein 126A
• NCBI Official Synonym Full Names: transmembrane protein 126A
• NCBI Official Symbol: TMEM126A
• NCBI Official Synonym Symbols: OPA7
• NCBI Protein Information: transmembrane protein 126A
• UniProt Protein Name: Transmembrane protein 126A
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM126A
• UniProt Entry Name: T126A_HUMAN

NCBI Description

The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Description

TMEM126A: Defects in TMEM126A are the cause of optic atrophy type 7 (OPA7). A hereditary condition that features progressive visual loss in association with optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. OPA7 is an autosomal recessive juvenile-onset optic atrophy characterized by severe bilateral deficiency in visual acuity, optic disk pallor, and central scotoma. Belongs to the TMEM126 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Biological Process: optic nerve development

Disease: Optic Atrophy 7 With Or Without Auditory Neuropathy