TMED4 recombinant protein

TMED4 Protein, Human, Recombinant (mFc Tag)

Cat. Num. AAA8121517

• Gene Names: TMED4; HNLF; ERS25; p24a3; GMP25iso; p24alpha3
• Purity: >90% as determined by SDS-PAGE
• Synonyms: TMED4; TMED4 Protein; Human; Recombinant (mFc Tag); Human TMED4/ERS25 Protein (Fc Tag); ERS25 Protein; GMP25iso Protein; HNLF Protein; p24alpha3 Protein; transmembrane emp24 protein transport domain containing 4; TMED4 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Arg194

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Leu 30
• Tag: C-mouse IgG1-Fc
• Protein Construction: A DNA sequence encoding the human TMED4 (NP_872353.2)(Met1-Arg194) was expressed with the Fc region of mouse IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for TMED4 recombinant protein

Background: TMED4, also known as ERS25, belongs to the EMP24/GP25L family. TMED4 may play a role in the regulation of heat-shock response and apoptosis. It is involved in vesicular protein trafficking, mainly in the early secretory pathway. TMED4 may also play a role in the biosynthesis of secreted cargo including processing. It functions in the regulation of heat-shock response and apoptosis. TMED4 also is involved in endoplasmic reticulum stress response.

References

Hartley JL. et al., 2001, Genome Res. 10 (11): 1788-95. Matoba R. et al., 1994, Gene. 146 (2): 199-207. Matsuda A. et al., 2003, Oncogene. 22 (21): 3307-18.

NCBI and Uniprot Product Information

• NCBI GI #: 33457308
• NCBI GeneID: 222068
• NCBI Accession #: NP_872353.2
• NCBI GenBank Nucleotide #: NM_182547.3
• UniProt Accession #: Q7Z7H5; Q56VW3; Q7Z432; Q8N2P6; A4D2K8; B4DFJ4
• Molecular Weight: 24,070 Da
• NCBI Official Full Name: transmembrane emp24 domain-containing protein 4 isoform 1
• NCBI Official Synonym Full Names: transmembrane p24 trafficking protein 4
• NCBI Official Symbol: TMED4
• NCBI Official Synonym Symbols: HNLF; ERS25; p24a3; GMP25iso; p24alpha3
• NCBI Protein Information: transmembrane emp24 domain-containing protein 4
• UniProt Protein Name: Transmembrane emp24 domain-containing protein 4
• Protein Family: Transmembrane emp24 domain-containing protein
• UniProt Gene Name: TMED4
• UniProt Synonym Gene Names: ERS25; ERS25; p24alpha3

Uniprot Description

Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis ().