Mouse toll-like receptor adaptor molecule 1 ELISA Kit | TICAM1 elisa kit
Mouse TIR domain-containing adapter molecule 1, TICAM1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.
Protein type: Apoptosis; Adaptor/scaffold
Molecular Function: protein binding; signal transducer activity; protein kinase binding
Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; immune system process; apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of protein homodimerization activity; positive regulation of interleukin-6 production; response to lipopolysaccharide; signal transduction; positive regulation of tumor necrosis factor production; positive regulation of natural killer cell activation; activation of NF-kappaB transcription factor; positive regulation of chemokine biosynthetic process; response to exogenous dsRNA; positive regulation of protein ubiquitination; positive regulation of B cell activation; positive regulation of interferon-beta biosynthetic process; macrophage activation during immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon type I production; positive regulation of B cell proliferation; innate immune response; inflammatory response; defense response to virus
Research Articles on TICAM1
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Product Notes
The Mouse TICAM1 ticam1 (Catalog #AAA9323601) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323601 ELISA Kit recognizes Mouse TICAM1. It is sometimes possible for the material contained within the vial of "toll-like receptor adaptor molecule 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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