T-lymphoma invasion and metastasis-inducing protein 2 (Tiam2) Recombinant Protein | Tiam2 recombinant protein

Recombinant Mouse T-lymphoma invasion and metastasis-inducing protein 2 (Tiam2) , partial

• Gene Names: Tiam2; STEF; mKIAA2016; 3000002F19Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: T-lymphoma invasion and metastasis-inducing protein 2 (Tiam2); Recombinant Mouse T-lymphoma invasion and metastasis-inducing protein 2 (Tiam2); partial; Tiam2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1715

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Tiam2 recombinant protein

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 176866834
• NCBI GeneID: 24001
• NCBI Accession #: NP_001116470.1
• NCBI GenBank Nucleotide #: NM_001122998.1
• UniProt Accession #: Q6ZPF3; Q3TSM6; Q3TZ33; Q6AXF2; Q6NXJ2; Q9JLY2; Q9WVS3
• Molecular Weight: 87,583 Da
• NCBI Official Full Name: T-lymphoma invasion and metastasis-inducing protein 2 isoform 1
• NCBI Official Synonym Full Names: T cell lymphoma invasion and metastasis 2
• NCBI Official Symbol: Tiam2
• NCBI Official Synonym Symbols: STEF; mKIAA2016; 3000002F19Rik
• NCBI Protein Information: T-lymphoma invasion and metastasis-inducing protein 2
• UniProt Protein Name: T-lymphoma invasion and metastasis-inducing protein 2
• Protein Family: T-lymphoma invasion and metastasis-inducing protein
• UniProt Gene Name: Tiam2
• UniProt Synonym Gene Names: Kiaa2016; Stef; TIAM-2

Uniprot Description

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.