Mouse T-cell lymphoma invasion and metastasis 2 ELISA Kit | TIAM2 elisa kit
Mouse T-lymphoma invasion and metastasis-inducing protein 2, TIAM2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TIAM2: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA. Belongs to the TIAM family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Rac/Rho; Apoptosis
Cellular Component: cell projection; membrane; cytoplasm
Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; receptor signaling protein activity; GTPase activator activity
Biological Process: regulation of Rho protein signal transduction; signal transduction; positive regulation of GTPase activity
Research Articles on TIAM2
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Product Notes
The Mouse TIAM2 tiam2 (Catalog #AAA9331571) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331571 ELISA Kit recognizes Mouse TIAM2. It is sometimes possible for the material contained within the vial of "T-cell lymphoma invasion and metastasis 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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