Human TIA1 cytotoxic granule-associated RNA binding protein-like 1 ELISA Kit | TIAL1 elisa kit

Human Nucleolysin TIAR, TIAL1 ELISA Kit

Cat. Num. AAA9342250

• Gene Names: TIAL1; TCBP; TIAR
• Reactivity: Human
• Synonyms: TIA1 cytotoxic granule-associated RNA binding protein-like 1; Human Nucleolysin TIAR; TIAL1 ELISA Kit; Human Nucleolysin TIAR (TIAL1) ELISA kit; MGC33401; TCBP; TIAR; T-cluster binding protein; TIA-1 related protein; TIA-1-related nucleolysin; TIA1 cytotoxic granule-associated RNA-binding protein-like 1; aging-associated gene 7 protein; TIAL1 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Assay Type: Quantitative Sandwich
• Detection Range: 0.625 ng/ml - 20 ng/ml
• Sensitivity: 0.1 ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for TIAL1 elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of TIAL1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 77695912
• NCBI GeneID: 7073
• NCBI Accession #: NP_001029097.1
• NCBI GenBank Nucleotide #: NM_001033925.1
• UniProt Accession #: Q01085; A8K3T0; A8K4L9
• Molecular Weight: 41,591 Da
• NCBI Official Full Name: nucleolysin TIAR isoform 2
• NCBI Official Synonym Full Names: TIA1 cytotoxic granule-associated RNA binding protein-like 1
• NCBI Official Symbol: TIAL1
• NCBI Official Synonym Symbols: TCBP; TIAR
• NCBI Protein Information: nucleolysin TIAR; T-cluster binding protein; TIA-1-related nucleolysin; aging-associated gene 7 protein
• UniProt Protein Name: Nucleolysin TIAR
• Protein Family: Nucleolysin
• UniProt Gene Name: TIAL1
• UniProt Entry Name: TIAR_HUMAN

NCBI Description

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

Uniprot Description

TIAL1: a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described.

Protein type: Apoptosis; RNA-binding

Chromosomal Location of Human Ortholog: 10q

Cellular Component: stress granule; lysosome; cytoplasm; nucleus

Molecular Function: RNA binding; nucleotide binding; AU-rich element binding

Biological Process: regulation of transcription from RNA polymerase II promoter; apoptosis; stem cell division; positive regulation of cell proliferation; defense response; germ cell development