SDS-Page
Thrombospondin Type-1 Domain-Containing 7A Recombinant Protein | THSD7A recombinant protein
Recombinant Human Thrombospondin Type-1 Domain-Containing Protein 7A, THSD7A
Applications
Western Blot
Purity
Affinity chromatography. >95% as estimated by SDS-PAGE stained with Instant Blue Stain (Expedeon).
Synonyms
Thrombospondin Type-1 Domain-Containing 7A; Recombinant Human Thrombospondin Type-1 Domain-Containing Protein 7A; THSD7A; Thrombospondin Type-1 Domain-Containing Protein 7A; THSD7A recombinant protein
Host
HEK293 Cells
Purity/Purification
Affinity chromatography. >95% as estimated by SDS-PAGE stained with Instant Blue Stain (Expedeon).
Form/Format
Liquid. PBS 20% Glycerol
Sequence Positions
48-1171aa
Sequence
AAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGSGHHHHHHHHHH
Applicable Applications for THSD7A recombinant protein
Western Blot (WB), Immunoassay (IA), Functional Studies
Source
Human
Tag
10xHis at the C-terminus
Endotoxin
Less than 0.1ng/ug (1 IEU/ug), as measured by LAL method.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at -20 degree or -70 degree C for at least 12 months
Shipping: Dry ice or frozen gel packs
Shipping: Dry ice or frozen gel packs
SDS-Page
SDS-Page
Related Product Information for THSD7A recombinant protein
THSD7A was first identified as an endothelial protein that is expressed in the vascularsystem of the placenta (1). It is expressed by cells of endothelial and neuronal lineage. The soluble form of THSD7A promotes endothelial cell migration and filopodia formation during angiogenesis via a FAK-dependent mechanism (2). This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineraldensity in osteoporosis.
THSD7A is expressed on podocytes and is responsible for 2-5% of patients with idiopathicmembranous nephropathy (3, 4, 5).
THSD7A is expressed on podocytes and is responsible for 2-5% of patients with idiopathicmembranous nephropathy (3, 4, 5).
References
Fresquet M., Rhoden S.J., Jowitt TA., McKenzie EA., Roberts I., Lennon R. and PE. Brenchley. Autoantigens PLA2R1 and THSD7A in Membranous Nephropathy Share a Common Epitope Motif in the N-terminal Domain. Journal of Autoimmunity. 106, pp 1-12. 2020.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
185,363 Da
NCBI Official Full Name
thrombospondin type-1 domain-containing protein 7A
NCBI Official Synonym Full Names
thrombospondin type 1 domain containing 7A
NCBI Official Symbol
THSD7A
NCBI Protein Information
thrombospondin type-1 domain-containing protein 7A
UniProt Protein Name
Thrombospondin type-1 domain-containing protein 7A
Protein Family
UniProt Gene Name
THSD7A
UniProt Synonym Gene Names
KIAA0960
NCBI Description
The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]
Uniprot Description
Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement.
Research Articles on THSD7A
Similar Products
Product Notes
The THSD7A thsd7a (Catalog #AAA184013) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 48-1171aa. AAA Biotech's Thrombospondin Type-1 Domain-Containing 7A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoassay (IA), Functional Studies. Researchers should empirically determine the suitability of the THSD7A thsd7a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: AAQGEAEAPT LYLWKTGPWG RCMGDECGPG GIQTRAVWCA HVEGWTTLHT NCKQAERPNN QQNCFKVCDW HKELYDWRLG PWNQCQPVIS KSLEKPLECI KGEEGIQVRE IACIQKDKDI PAEDIICEYF EPKPLLEQAC LIPCQQDCIV SEFSAWSECS KTCGSGLQHR TRHVVAPPQF GGSGCPNLTE FQVCQSSPCE AEELRYSLHV GPWSTCSMPH SRQVRQARRR GKNKEREKDR SKGVKDPEAR ELIKKKRNRN RQNRQENKYW DIQIGYQTRE VMCINKTGKA ADLSFCQQEK LPMTFQSCVI TKECQVSEWS EWSPCSKTCH DMVSPAGTRV RTRTIRQFPI GSEKECPEFE EKEPCLSQGD GVVPCATYGW RTTEWTECRV DPLLSQQDKR RGNQTALCGG GIQTREVYCV QANENLLSQL STHKNKEASK PMDLKLCTGP IPNTTQLCHI PCPTECEVSP WSAWGPCTYE NCNDQQGKKG FKLRKRRITN EPTGGSGVTG NCPHLLEAIP CEEPACYDWK AVRLGNCEPD NGKECGPGTQ VQEVVCINSD GEEVDRQLCR DAIFPIPVAC DAPCPKDCVL STWSTWSSCS HTCSGKTTEG KQIRARSILA YAGEEGGIRC PNSSALQEVR SCNEHPCTVY HWQTGPWGQC IEDTSVSSFN TTTTWNGEAS CSVGMQTRKV ICVRVNVGQV GPKKCPESLR PETVRPCLLP CKKDCIVTPY SDWTSCPSSC KEGDSSIRKQ SRHRVIIQLP ANGGRDCTDP LYEEKACEAP QACQSYRWKT HKWRRCQLVP WSVQQDSPGA QEGCGPGRQA RAITCRKQDG GQAGIHECLQ YAGPVPALTQ ACQIPCQDDC QLTSWSKFSS CNGDCGAVRT RKRTLVGKSK KKEKCKNSHL YPLIETQYCP CDKYNAQPVG NWSDCILPEG KVEVLLGMKV QGDIKECGQG YRYQAMACYD QNGRLVETSR CNSHGYIEEA CIIPCPSDCK LSEWSNWSRC SKSCGSGVKV RSKWLREKPY NGGRPCPKLD HVNQAQVYEV VPCHSDCNQY LWVTEPWSIC KVTFVNMREN CGEGVQTRKV RCMQNTADGP SEHVEDYLCD PEEMPLGSRV CKLPCPEDCV ISEWGSGHHH HHHHHHH. It is sometimes possible for the material contained within the vial of "Thrombospondin Type-1 Domain-Containing 7A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
