Thrombospondin Type-1 Domain-Containing 7A Recombinant Protein | THSD7A recombinant protein

Recombinant Human Thrombospondin Type-1 Domain-Containing Protein 7A, THSD7A

Cat. Num. AAA184013

• Applications: Western Blot
• Purity: Affinity chromatography. >95% as estimated by SDS-PAGE stained with Instant Blue Stain (Expedeon).
• Synonyms: Thrombospondin Type-1 Domain-Containing 7A; Recombinant Human Thrombospondin Type-1 Domain-Containing Protein 7A; THSD7A; Thrombospondin Type-1 Domain-Containing Protein 7A; THSD7A recombinant protein

• Host: HEK293 Cells
• Purity/Purification: Affinity chromatography. >95% as estimated by SDS-PAGE stained with Instant Blue Stain (Expedeon).
• Form/Format: Liquid. PBS 20% Glycerol
• Sequence Positions: 48-1171aa
• Sequence: AAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGSGHHHHHHHHHH

• Applicable Applications for THSD7A recombinant protein: Western Blot (WB), Immunoassay (IA), Functional Studies
• Source: Human
• Tag: 10xHis at the C-terminus
• Endotoxin: Less than 0.1ng/ug (1 IEU/ug), as measured by LAL method.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store at -20 degree or -70 degree C for at least 12 months; Shipping: Dry ice or frozen gel packs

SDS-Page

Related Product Information for THSD7A recombinant protein

THSD7A was first identified as an endothelial protein that is expressed in the vascularsystem of the placenta (1). It is expressed by cells of endothelial and neuronal lineage. The soluble form of THSD7A promotes endothelial cell migration and filopodia formation during angiogenesis via a FAK-dependent mechanism (2). This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineraldensity in osteoporosis.
THSD7A is expressed on podocytes and is responsible for 2-5% of patients with idiopathicmembranous nephropathy (3, 4, 5).

References

Fresquet M., Rhoden S.J., Jowitt TA., McKenzie EA., Roberts I., Lennon R. and PE. Brenchley. Autoantigens PLA2R1 and THSD7A in Membranous Nephropathy Share a Common Epitope Motif in the N-terminal Domain. Journal of Autoimmunity. 106, pp 1-12. 2020.

NCBI and Uniprot Product Information

• NCBI GI #: 150170672
• NCBI GeneID: 221981
• NCBI Accession #: NP_056019.1
• NCBI GenBank Nucleotide #: NM_015204.2
• UniProt Accession #: Q9UPZ6
• Molecular Weight: 185,363 Da
• NCBI Official Full Name: thrombospondin type-1 domain-containing protein 7A
• NCBI Official Synonym Full Names: thrombospondin type 1 domain containing 7A
• NCBI Official Symbol: THSD7A
• NCBI Protein Information: thrombospondin type-1 domain-containing protein 7A
• UniProt Protein Name: Thrombospondin type-1 domain-containing protein 7A
• Protein Family: Thrombospondin type-1 domain-containing protein
• UniProt Gene Name: THSD7A
• UniProt Synonym Gene Names: KIAA0960

NCBI Description

The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

Uniprot Description

Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement.