Human THO complex 6 homolog (Drosophila) ELISA Kit | THOC6 elisa kit
Human THO complex subunit 6 homolog, THOC6 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
THOC6: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the WD repeat THOC6 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Spliceosome; RNA splicing
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: nucleoplasm; nuclear speck; nucleus
Molecular Function: RNA binding
Biological Process: mRNA export from nucleus; central nervous system development; apoptosis; RNA splicing; intronless viral mRNA export from host nucleus; mRNA processing; negative regulation of apoptosis
Disease: Beaulieu-boycott-innes Syndrome
Research Articles on THOC6
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Product Notes
The Human THOC6 thoc6 (Catalog #AAA9325978) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325978 ELISA Kit recognizes Human THOC6. It is sometimes possible for the material contained within the vial of "THO complex 6 homolog (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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