THAP domain-containing protein 11 Recombinant Protein | THAP11 recombinant protein

Recombinant Human THAP domain-containing protein 11

Cat. Num. AAA1399793

• Gene Names: THAP11; RONIN; CTG-B43a; CTG-B45d; HRIHFB2206
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: THAP domain-containing protein 11; Recombinant Human THAP domain-containing protein 11; THAP11 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-313aa; Partial
• Sequence: MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAGVSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVSASAAVLLTLQATVDSSQAPGSVQPAPITPTGEDVKPIDLTVQVEFAAAEGAAAAAAASELQAATAGLEAAECPMGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHG
• Sequence Length: 314

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for THAP11 recombinant protein

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic st (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.

Product Categories/Family for THAP11 recombinant protein

Epigenetics and Nuclear Signaling

References

Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Searching for interaction partners of the transcription factor REST/NRSF by two-hybrid screening.Santana-Roman H., Curiel-Quesada E., Tapia-Ramirez J.Selection system for genes encoding nuclear-targeted proteins.Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.Nat. Biotechnol. 16:1338-1342(1998) SMARCA2 and THAP11 potential candidates for polyglutamine disorders as evidenced from polymorphism and protein-folding simulation studies.Pandey N., Mittal U., Srivastava A.K., Mukerji M.J. Hum. Genet. 49:596-602(2004) NMR studies of a new family of DNA binding proteins the THAP proteins.Gervais V., Campagne S., Durand J., Muller I., Milon A.J. Biomol. NMR 56:3-15(2013)

NCBI and Uniprot Product Information

• NCBI GI #: 40354197
• NCBI GeneID: 57215
• NCBI Accession #: NP_065190.2
• NCBI GenBank Nucleotide #: NM_020457.2
• UniProt Accession #: Q96EK4; O94795; A4UCT5; A8K002
• Molecular Weight: 50.3 kDa
• NCBI Official Full Name: THAP domain-containing protein 11
• NCBI Official Synonym Full Names: THAP domain containing 11
• NCBI Official Symbol: THAP11
• NCBI Official Synonym Symbols: RONIN; CTG-B43a; CTG-B45d; HRIHFB2206
• NCBI Protein Information: THAP domain-containing protein 11
• UniProt Protein Name: THAP domain-containing protein 11
• Protein Family: THAP domain-containing protein
• UniProt Gene Name: THAP11
• UniProt Entry Name: THA11_HUMAN

NCBI Description

The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]

Uniprot Description

THAP11: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. Belongs to the THAP11 family. Interacts (via coiled coil domain) with HCFC1.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; intercellular bridge; nucleoplasm

Molecular Function: DNA binding; protein binding; zinc ion binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent