Trimethylguanosine synthase Recombinant Protein | TGS1 recombinant protein
Recombinant Human Trimethylguanosine synthase
Gene Names
TGS1; PIMT; PIPMT; NCOA6IP
Reactivity
Human
Purity
Greater than 90% as determined by SDS-PAGE.
Synonyms
Trimethylguanosine synthase; Recombinant Human Trimethylguanosine synthase; CLL-associated antigen KW-2; Cap-specific guanine-N2 methyltransferaseHepatocellular carcinoma-associated antigen 137Nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif; PIMT; PIPMT; TGS1 recombinant protein
Host
E Coli
Reactivity
Human
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Sequence Positions
Partial, 713-853aa
Tag Info
His-SUMO-tag
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Related Product Information for TGS1 recombinant protein
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2, 2, 7-trimethylguanosine (m (2, 2, 7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
31.64kD
NCBI Official Full Name
trimethylguanosine synthase isoform 2
NCBI Official Synonym Full Names
trimethylguanosine synthase 1
NCBI Official Symbol
TGS1
NCBI Official Synonym Symbols
PIMT; PIPMT; NCOA6IP
NCBI Protein Information
trimethylguanosine synthase
UniProt Protein Name
Trimethylguanosine synthase
Protein Family
UniProt Gene Name
TGS1
UniProt Synonym Gene Names
HCA137; NCOA6IP; PIMT; PIMT; PIPMT
Uniprot Description
PIMT: a nuclear protein and apparent methyltransferase. Binds S-adenosyl-L-methionine and RNA. Plays a role in transcriptional regulation. Interacts with NCOA, CBP, p300, and PPARBP. Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.
Protein type: EC 2.1.1.-; Methyltransferase; Nuclear receptor co-regulator; RNA processing
Chromosomal Location of Human Ortholog: 8q12.1
Cellular Component: cytoplasm; cytosol; extracellular space; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex
Molecular Function: protein binding; RNA methyltransferase activity
Biological Process: regulation of lipid metabolic process; ribonucleoprotein complex biogenesis and assembly; spliceosomal snRNP biogenesis
Research Articles on TGS1
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Product Notes
The TGS1 tgs1 (Catalog #AAA9421328) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Partial, 713-853aa. The Recombinant Human Trimethylguanosine synthase reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Trimethylguanosine synthase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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