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Transforming Growth Factor-Beta 3 Recombinant Protein | TGF b 3 recombinant protein

Recombinant Human Transforming Growth Factor-Beta 3 (644-850)

Gene Names
TGFB3; ARVD; RNHF; ARVD1; TGF-beta3
Applications
ELISA, Western Blot
Synonyms
Transforming Growth Factor-Beta 3; Recombinant Human Transforming Growth Factor-Beta 3 (644-850); TGF b 3 (207 a.a.) Human; Transforming Growth Factor-Beta 3 (207 a.a.) Human Recombinant; Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3; TGF b 3 (207 a.a.); TGF b 3 recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Form/Format
100 ul purified human TGF Beta 3protein at 100 ug/ml in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Sterile Filtered clear solution.
Sequence Length
412
Applicable Applications for TGF b 3 recombinant protein
ELISA (EIA), Inhibition Assays, Western Blot (WB)
Preparation and Storage
TGF-beta 3 Human Recombinant although stable at 4 degree C for 1 week, should be stored at -20 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze-thaw cycles.
Related Product Information for TGF b 3 recombinant protein
Description: TGFB3 Human Recombinant protein encoding amino acids 644-850 and total molecular mass of 50 kDa (Including GST Tag).

Introduction: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
Product Categories/Family for TGF b 3 recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
35,708 Da
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor, beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; RNHF; ARVD1; TGF-beta3
NCBI Protein Information
transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3
UniProt Protein Name
Transforming growth factor beta-3
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN

NCBI Description

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

Uniprot Description

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Ligand, receptor tyrosine kinase; Secreted, signal peptide; Cell development/differentiation; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; SMAD protein nuclear translocation; female pregnancy; palate development; regulation of apoptosis; odontogenesis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; uterine wall breakdown; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; gut development; positive regulation of protein secretion; response to estrogen stimulus; negative regulation of DNA replication; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; blood coagulation; response to progesterone stimulus; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

Research Articles on TGF b 3

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Product Notes

The TGF b 3 tgfb3 (Catalog #AAA142196) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Transforming Growth Factor-Beta 3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition Assays, Western Blot (WB). Researchers should empirically determine the suitability of the TGF b 3 tgfb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transforming Growth Factor-Beta 3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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