Transcription factor EC (TFEC) Recombinant Protein | TFEC recombinant protein

Recombinant Human Transcription factor EC (TFEC)

Cat. Num. AAA1048254

• Gene Names: TFEC; TCFEC; TFE-C; TFECL; TFEC-L; bHLHe34; hTFEC-L
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transcription factor EC (TFEC); Recombinant Human Transcription factor EC (TFEC); TFEC recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-347, Full length protein
• Sequence: MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSATSPAVSKESSRRSSFSSDDGDEL
• Sequence Length: 347

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 64762402
• NCBI GeneID: 22797
• NCBI Accession #: NP_001018068.1
• NCBI GenBank Nucleotide #: NM_001018058.2
• UniProt Accession #: O14948; Q5H9U8; Q709A4; Q8N6J9; B2R8X5
• Molecular Weight: 31,558 Da
• NCBI Official Full Name: transcription factor EC isoform b
• NCBI Official Synonym Full Names: transcription factor EC
• NCBI Official Symbol: TFEC
• NCBI Official Synonym Symbols: TCFEC; TFE-C; TFECL; TFEC-L; bHLHe34; hTFEC-L
• NCBI Protein Information: transcription factor EC
• UniProt Protein Name: Transcription factor EC
• Protein Family: Transcription factor
• UniProt Gene Name: TFEC
• UniProt Synonym Gene Names: BHLHE34; TCFEC; TFECL; TFE-C; bHLHe34; hTFEC-L

NCBI Description

This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Uniprot Description

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (). Collaborates with MITF in target gene activation (). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (). Binds DNA in a homo- or heterodimeric form.