Mouse transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) ELISA Kit | TFAP2A elisa kit

Mouse Transcription factor AP-2-alpha, TFAP2A ELISA Kit

Cat. Num. AAA9340273

• Gene Names: Tfap2a; Ap2; AP-2; Ap2tf; Tcfap2a; AP2alpha; Ap-2 (a)
• Reactivity: Mouse
• Synonyms: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Mouse Transcription factor AP-2-alpha; TFAP2A ELISA Kit; Mouse Transcription factor AP-2-alpha (TFAP2A) ELISA kit; AP-2; AP-2alpha; AP2TF; BOFS; FLJ51761; TFAP2; transcription factor AP-2 alpha; TFAP2A elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 31981462
• NCBI GeneID: 21418
• NCBI Accession #: NP_035677.2
• NCBI GenBank Nucleotide #: NM_011547.4
• UniProt Accession #: P34056; Q60740; Q60741; Q60742; Q60743; Q62067; Q62068; Q62069; Q91VX0; Q9CRY4
• Molecular Weight: 47,971 Da
• NCBI Official Full Name: transcription factor AP-2-alpha isoform a
• NCBI Official Synonym Full Names: transcription factor AP-2, alpha
• NCBI Official Symbol: Tfap2a
• NCBI Official Synonym Symbols: Ap2; AP-2; Ap2tf; Tcfap2a; AP2alpha; Ap-2 (a)
• NCBI Protein Information: transcription factor AP-2-alpha; activator protein 2; activating enhancer-binding protein 2 alpha
• UniProt Protein Name: Transcription factor AP-2-alpha
• Protein Family: Transcription factor
• UniProt Gene Name: Tfap2a
• UniProt Synonym Gene Names: Ap2tf; Tcfap2a; AP2-alpha; AP-2
• UniProt Entry Name: AP2A_MOUSE

NCBI Description

This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]

Uniprot Description

AP-2 alpha: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A- transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2. Belongs to the AP-2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; Golgi apparatus; centrosome; transcription factor complex; intracellular membrane-bound organelle; cytoplasm; cytosol; nucleus

Molecular Function: protein dimerization activity; protein binding; DNA binding; sequence-specific DNA binding; transcription coactivator activity; chromatin binding; transcription factor binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; embryonic forelimb morphogenesis; skin development; negative regulation of epidermal growth factor receptor signaling pathway; neural crest cell development; regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; palate development; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; forelimb morphogenesis; negative regulation of cell proliferation; sympathetic nervous system development; sensory perception of sound; oculomotor nerve formation; regulation of transcription, DNA-dependent; epidermis morphogenesis; regulation of cell differentiation; positive regulation of neuron apoptosis; negative regulation of neuron apoptosis; kidney development; trigeminal nerve development; inner ear morphogenesis; transcription, DNA-dependent; anterior neuropore closure; embryonic cranial skeleton morphogenesis; positive regulation of bone mineralization; regulation of transcription from RNA polymerase II promoter; embryonic body morphogenesis; skeletal morphogenesis; forebrain neuron development; neural tube closure; lens morphogenesis in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; negative regulation of apoptosis