SDS-Page
(15% SDS-PAGE using T9013-95H (3ug))
Tryptophan 2,3-Dioxygenase, aa1-406 Recombinant Protein | TDO2 recombinant protein
Tryptophan 2,3-Dioxygenase, aa1-406, Recombinant, Human (TDO, TDO2, TPH2, Tryptamin 2,3-dioxygenase, Tryptophan Oxygenase, TO, TRPO, Tryptophan Pyrrolase, Tryptophanase)
~90% (SDS-PAGE)
~90% (SDS-PAGE)
SDS-Page
(15% SDS-PAGE using T9013-95H (3ug))
SDS-Page
(15% SDS-PAGE using T9013-95H (3ug))
Recombinant protein corresponding to human TDO2, fused to His-tag at N-terminus, expressed in E. coli.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
Uniprot Description
TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family.
Protein type: Oxidoreductase; EC 1.13.11.11; Amino Acid Metabolism - tryptophan
Chromosomal Location of Human Ortholog: 4q31-q32
Cellular Component: cytosol
Molecular Function: amino acid binding; metal ion binding; heme binding; oxygen binding; tryptophan 2,3-dioxygenase activity
Biological Process: tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; tryptophan catabolic process
Research Articles on TDO2
Similar Products
Product Notes
The TDO2 tdo2 (Catalog #AAA636348) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tryptophan 2,3-Dioxygenase, aa1-406, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
