CRIPTO Blocking Peptide | TDGF1 blocking peptide
CRIPTO Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Description
TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis; Membrane protein, peripheral; Cell adhesion; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: apical plasma membrane; cell surface; extracellular space; extrinsic to plasma membrane; lipid raft; plasma membrane
Molecular Function: growth factor activity; protein binding; receptor binding
Biological Process: activation of MAPK activity; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; embryonic development; epidermal growth factor receptor signaling pathway; heart development; mammary gland development; morphogenesis of a branching structure; negative regulation of apoptosis; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signal transduction; somatic stem cell maintenance
Research Articles on TDGF1
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Product Notes
The TDGF1 tdgf1 (Catalog #AAA425217) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The CRIPTO Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: YGRNCEHDVR KEN. It is sometimes possible for the material contained within the vial of "CRIPTO, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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