TCL1A recombinant protein

TCL1A, 1-114aa, Human, E Coli

Cat. Num. AAA203392

• Gene Names: TCL1A; TCL1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: TCL1A; 1-114aa; Human; E Coli; T-cell leukemia/lymphoma 1A; TCL1; TCL-1; protein p14TCL1; Oncogene TCL1; T-cell leukemia/lymphoma 1A anti TCL1A; P14 TCL1; P14 TCL1 protein; T cell leukemia 1; T cell lymphoma 1; T cell lymphoma 1A; TCL 1 protein; TCL1 oncogene; TCL1 PEN; TCL1A.; TCL1A recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 50mM Tris-HCl Buffer (pH 7.5) containing 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
• Sequence Length: 114

• Applicable Applications for TCL1A recombinant protein: SDS-PAGE
• Antigen Species: Human
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for TCL1A recombinant protein

TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism. Recombinant TCL1A protein was expressed in E Coli and purified by using conventional chromatography techniques

Product Categories/Family for TCL1A recombinant protein

Signal Transduction

References

Herling M., et al. (2006) Leukemia. 20 (2):280-5.; Hoyer KK., et al. (2005) J Immunol. 175 (2):864-73.;

NCBI and Uniprot Product Information

• NCBI GI #: 148922879
• NCBI GeneID: 8115
• NCBI Accession #: NP_001092195
• NCBI GenBank Nucleotide #: NM_001098725.1
• UniProt Accession #: P56279; Q6IBK7
• Molecular Weight: 13.4 kDa (114aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
• NCBI Official Full Name: T-cell leukemia/lymphoma protein 1A
• NCBI Official Synonym Full Names: T cell leukemia/lymphoma 1A
• NCBI Official Symbol: TCL1A
• NCBI Official Synonym Symbols: TCL1
• NCBI Protein Information: T-cell leukemia/lymphoma protein 1A
• UniProt Protein Name: T-cell leukemia/lymphoma protein 1A
• Protein Family: T-cell leukemia/lymphoma protein
• UniProt Gene Name: TCL1A
• UniProt Synonym Gene Names: TCL1; Oncogene TCL1

NCBI Description

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

Uniprot Description

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.