Hamster T-Box Protein 3 ELISA Kit | TBX3 elisa kit

Hamster T-Box Protein 3 ELISA Kit

Cat. Num. AAA45750

• Gene Names: TBX3; UMS; XHL; TBX3-ISO
• Reactivity: Hamster
• Synonyms: T-Box Protein 3; Hamster T-Box Protein 3 ELISA Kit; TBX3 elisa kit

• Reactivity: Hamster
• Sequence Length: 743

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 47419907
• NCBI GeneID: 6926
• NCBI Accession #: NP_057653.3
• NCBI GenBank Nucleotide #: NM_016569.3
• UniProt Accession #: O15119; Q8TB20; Q9UKF8
• Molecular Weight: 79,389 Da
• NCBI Official Full Name: T-box transcription factor TBX3 isoform 2
• NCBI Official Synonym Full Names: T-box 3
• NCBI Official Symbol: TBX3
• NCBI Official Synonym Symbols: UMS; XHL; TBX3-ISO
• NCBI Protein Information: T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL
• UniProt Protein Name: T-box transcription factor TBX3
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX3
• UniProt Synonym Gene Names: T-box protein 3
• UniProt Entry Name: TBX3_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q24.21

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; limbic system development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; palate development; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; positive regulation of cell cycle; cell aging; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; negative regulation of apoptosis

Disease: Ulnar-mammary Syndrome