Sec-independent protein translocase protein TatC (tatC) Recombinant Protein | tatC recombinant protein

Recombinant Escherichia coli Sec-independent protein translocase protein TatC (tatC)

• Gene Names: tatC; ECK3832; JW3815; mttB; yigU; yigV
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sec-independent protein translocase protein TatC (tatC); Recombinant Escherichia coli Sec-independent protein translocase protein TatC (tatC); Recombinant Sec-independent protein translocase protein TatC (tatC); Sec-independent protein translocase protein TatC; tatC recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-258
• Sequence: SVEDTQPLITHLIELRKRLLNCIIAVIVIFLCLVYFANDIYHLVSAPLIKQLPQGSTMIATDVASPFFTPIKLTFMVSLILSAPVILYQVWAFIAPALYKHERRLVVPLLVSSSLLFYIGMAFAYFVVFPLAFGFLANTAPEGVQVSTDIASYLSFVMALFMAFGVSFEVPVAIVLLCWMGITSPEDLRKKRPYVLVGAFVVGMLLTPPDVFSQTLLAIPMYCLFEIGVFFSRFYVGKGRNREEENDAEAESEKTEE
• Sequence Length: 258

• Species: Escherichia coli (strain K12)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 16131687
• NCBI GeneID: 948328
• NCBI Accession #: NP_418282.1
• NCBI GenBank Nucleotide #: NC_000913.2
• UniProt Accession #: P69423; P27857; P27858; P76765; P76766; Q2M8E3
• Molecular Weight: 28,876 Da
• NCBI Official Full Name: TatABCE protein translocation system subunit
• NCBI Official Symbol: tatC
• NCBI Official Synonym Symbols: ECK3832; JW3815; mttB; yigU; yigV
• NCBI Protein Information: TatABCE protein translocation system subunit
• UniProt Protein Name: Sec-independent protein translocase protein TatC
• Protein Family: Sec-independent protein translocase protein
• UniProt Gene Name: tatC
• UniProt Synonym Gene Names: mttB; yigU; yigV
• UniProt Entry Name: TATC_ECOLI

NCBI Description

Topology mapped using protein fusions. [More information is available at EcoGene: EG11479]. TatC is a subunit of the TatABCE (twin-arginine translocation) complex for the export of folded proteins across the cytoplasmic membrane. [More information is available at EcoCyc: EG11479].

Uniprot Description

Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. Ref.7 Ref.12 Ref.15 Ref.21 Ref.22

Subunit structure: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. TatC can form a distinct, stable, multimeric complex independent of TatA and TatB. Each of TatA, TatB and TatC are able to interact in pairs without the third partner. Interacts with the signal sequence of DmsA and DmsD. Ref.6 Ref.16 Ref.17 Ref.18 Ref.20 Ref.23

Subcellular location: Cell inner membrane; Multi-pass membrane protein. Note: Localizes at the cell poles. Ref.9 Ref.16 Ref.23

Induction: Constitutively expressed. Ref.10

Disruption phenotype: Disruption blocks the export of at least five twin-arginine-containing precursor proteins that are predicted to bind redox cofactors, and hence fold prior to translocation. Disruption does not affect the Sec pathway. Ref.7

Sequence similarities: Belongs to the TatC family.