Transaldolase Recombinant Protein | TALDO1 recombinant protein

Recombinant Human Transaldolase

Cat. Num. AAA144103

• Gene Names: TALDO1; TAL; TALH; TAL-H; TALDOR
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Transaldolase; Recombinant Human Transaldolase; TALDO1 Human; Transaldolase Human Recombinant; TAL; TAL-H; TALDOR; TALH; TALDO1; TALDO1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: TALDO1 1mg/ml protein solution contains 20 mM Tris-HCl buffer (pH 8.0) and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSHMSSSPVKRQR MESALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL AAAQMPAYQE LVEEAIAYGR KLGGSQEDQIKNAIDKLFVL FGAEILKKIP GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGISKDRIL IKLSSTWEGIQAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN TDKKSYEPLE DPGVKSVTKI YNYYKKFSYKTIVMGASFRN TGEIKALAGC DFLTISPKLL GELLQDNAKL VPVLSAKAAQ ASDLEKIHLD EKSFRWLHNEDQMAVEKLSD GIRKFAADAV KLERMLTERM FNAENGK
• Sequence Length: 337

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for TALDO1 recombinant protein

Description: TALDO1 Human Recombinant protein produced in E Coli is a single, non-glycosylated, polypeptide chain containing 357 amino acids (1-337) and having a molecular mass of 39.7 kDa. TALDO1 is fused to 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.

Introduction: TALDO1 is a important enzyme of the non-oxidative pentose phosphate pathway supplying ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. TALDO1 delivers a dihydroxyacetone group from donor compounds (fructose 6-phosphate or sedoheptulose 7-phosphate) to aldehyde acceptor compounds. TALDO1 is expressed at selectively great levels in oligodendrocytes of the brain. TALDO1 Deficiency results in accumulation of erythritol, D-arabitol, and ribitol.

Product Categories/Family for TALDO1 recombinant protein

Enzymes; Aldolase

NCBI and Uniprot Product Information

• NCBI GI #: 5803187
• NCBI GeneID: 6888
• NCBI Accession #: NP_006746.1
• NCBI GenBank Nucleotide #: NM_006755.1
• UniProt Accession #: P37837; O00751; Q8WV32; Q8WZ45; B2R8M2
• Molecular Weight: 37,540 Da
• NCBI Official Full Name: transaldolase
• NCBI Official Synonym Full Names: transaldolase 1
• NCBI Official Symbol: TALDO1
• NCBI Official Synonym Symbols: TAL; TALH; TAL-H; TALDOR
• NCBI Protein Information: transaldolase; dihydroxyacetone transferase; glycerone transferase
• UniProt Protein Name: Transaldolase
• Protein Family: Transaldolase
• UniProt Gene Name: TALDO1
• UniProt Synonym Gene Names: TAL; TALDO; TALDOR
• UniProt Entry Name: TALDO_HUMAN

NCBI Description

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]

Uniprot Description

TALDO1: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency). It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris. Belongs to the transaldolase family. Type 1 subfamily.

Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.2; Transferase

Chromosomal Location of Human Ortholog: 11p15.5-p15.4

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: transaldolase activity

Biological Process: pentose-phosphate shunt; carbohydrate metabolic process; energy reserve metabolic process; pathogenesis; xylulose biosynthetic process

Disease: Transaldolase Deficiency