TAF I Blocking Peptide | TAFI blocking peptide

TAF I p48 (R318) Peptide

Cat. Num. AAA3002462

• Gene Names: TAF1A; SL1; RAFI48; TAFI48; MGC:17061
• Applications: Blocking
• Purity: Synthetic peptide TAF I p48 (R318). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: TAF I; TAF I p48 (R318) Peptide; SET; 2PP2A; I-2PP2A; I2PP2A; IGAAD; PHAPII; TAF-I; TAF-IBETA; TAFI blocking peptide

• Specificity: This peptide can be used with studies using MBS3002461 TAF I p48 (R318) pAb.
• Purity/Purification: Synthetic peptide TAF I p48 (R318). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 450

• Applicable Applications for TAFI blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for TAFI blocking peptide

For gene transcription governed by RNA polymerase I, the human transcription factor SL1 (mouse TIF-IB) directs the assembly of initiation complexes at the prompter. Like TFIID, which directs transcription by RNA polymerase II, SL1/TIF-IB contains the TATA-binding protein (TBP) and a set of TBP-associated factors (TAFs). The three TAF I subunits, hTAF I p110, hTAF I p63 and hTAF p48 (or mouse TAF I p95, TAF I p68 and TAF I p48) are all integral components of SL1/TIF-IB. The mutually exclusive binding of either TAF I or TAF II subunits to TBP is believed to direct the formation of promoter and RNA polymerase-specific complexes.

NCBI and Uniprot Product Information

• NCBI GI #: 319996599
• NCBI GeneID: 9015
• NCBI Accession #: NP_001188465.1
• NCBI GenBank Nucleotide #: NP_001188465.1
• UniProt Accession #: Q15573
• NCBI Official Full Name: TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor, RNA polymerase I subunit A
• NCBI Official Symbol: TAF1A
• NCBI Official Synonym Symbols: SL1; RAFI48; TAFI48; MGC:17061
• NCBI Protein Information: TATA box-binding protein-associated factor RNA polymerase I subunit A
• UniProt Protein Name: TATA box-binding protein-associated factor RNA polymerase I subunit A
• UniProt Gene Name: TAF1A
• UniProt Synonym Gene Names: TAFI48
• UniProt Entry Name: TAF1A_HUMAN

NCBI Description

This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

Uniprot Description

TAF1A: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q42

Cellular Component: microtubule cytoskeleton; nucleoplasm; intracellular membrane-bound organelle; RNA polymerase I transcription factor complex; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: transcription from RNA polymerase II promoter; chromatin silencing at rDNA; negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; regulation of gene expression, epigenetic