Human TATA box binding protein (TBP) -associated factor, RNA polymerase I, C, 110kDa ELISA Kit | TAF1C elisa kit

Human TATA box-binding protein-associated factor RNA polymerase I subunit C, TAF1C ELISA Kit

Cat. Num. AAA9338241

• Gene Names: TAF1C; SL1; TAFI95; TAFI110; MGC:39976
• Reactivity: Human
• Synonyms: TATA box binding protein (TBP) -associated factor; RNA polymerase I; C; 110kDa; Human TATA box-binding protein-associated factor RNA polymerase I subunit C; TAF1C ELISA Kit; Human TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C) ELISA kit; MGC:39976; SL1; TAFI110; TAFI95; 110kD subunit; TBP-associated factor 1C; transcription factor SL1; TAF1C elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
• Assay Type: Sandwich
• Detection Range: 0.625 ng/ml - 20 ng/ml.
• Sensitivity: 0.1 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for TAF1C elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of TAF1C (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 341926281
• NCBI GeneID: 9013
• NCBI Accession #: NP_001230085.1
• NCBI GenBank Nucleotide #: NM_001243156.1
• UniProt Accession #: Q15572; Q59F67; Q8N6V3; B7Z5K5; B7Z5S4; B7Z908; B7Z9L7
• Molecular Weight: 95,213 Da
• NCBI Official Full Name: TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 3
• NCBI Official Synonym Full Names: TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
• NCBI Official Symbol: TAF1C
• NCBI Official Synonym Symbols: SL1; TAFI95; TAFI110; MGC:39976
• NCBI Protein Information: TATA box-binding protein-associated factor RNA polymerase I subunit C; SL1, 110kD subunit; TBP-associated factor 1C; transcription factor SL1; TATA box-binding protein-associated factor 1C; transcription initiation factor SL1/TIF-IB subunit C; RNA polymerase I-specific TBP-associated factor 110 kDa; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD
• UniProt Protein Name: TATA box-binding protein-associated factor RNA polymerase I subunit C
• Protein Family: TATA box-binding protein-associated factor
• UniProt Gene Name: TAF1C
• UniProt Synonym Gene Names: TAFI110; TBP-associated factor 1C
• UniProt Entry Name: TAF1C_HUMAN

NCBI Description

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Uniprot Description

TAF1C: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: nucleoplasm

Molecular Function: protein binding; DNA binding

Biological Process: transcription from RNA polymerase II promoter; chromatin silencing at rDNA; negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; regulation of gene expression, epigenetic