TAF15 recombinant protein

Recombinant Human TAF15

Cat. Num. AAA145514

• Gene Names: TAF15; Npl3; RBP56; TAF2N; TAFII68
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: TAF15; Recombinant Human TAF15; TAF15 Human; TAF15 Human Recombinant; Npl3; RBP56; TAF2N; TAFII68; TATA-binding protein-associated factor 2N; 68 kDa TATA-binding protein-associated factor; RNA-binding protein 56; TAF15 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The TAF15 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSSYHSQRE NYSHHTQDDR RDVSRYGEDN RGYGGSQGGG RGRGGYDKDG RGPMTGSSGG DRGGFKNFGG HRDYGPRTDA DSESDNSDNN TIFVQGLGEG VSTDQVGEFF KQIGIIKTNK KTGKPMINLY TDKDTGKPKG EATVSFDDPP SAKAAIDWFD GKEFHGNIIK VSFATRRPEF MRGGGSGGGR RGRGGYRGRG GFQGRGGDPK SGDWVCPNPS CGNMNFARRN SCNQCNEPRP EDSRPSGGDF RGRGYGGERG YR
• Sequence Length: 589

Related Product Information for TAF15 recombinant protein

Description: TAF15 Human Recombinant produced in E Coli is. a single polypeptide chain containing 282 amino acids (148-406) and having a molecular mass of 30kDa. TAF15 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: TAF15 is a member of the TET family of RNA-binding proteins. TAF15 is a component of a subset of multi-subunit transcription initiation factor TFIID complexes which takes part in RNA polymerase II gene transcription. Translocations involving TAF15 are found in severe leukemia and extraskeletal myxoid chondrosarcoma. Mutations in TAF15 take part in amyotrophic lateral sclerosis.

Product Categories/Family for TAF15 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4507353
• NCBI GeneID: 8148
• NCBI Accession #: NP_003478.1
• NCBI GenBank Nucleotide #: NM_003487.3
• UniProt Accession #: Q92804; Q86X94; Q92751; B2R837
• Molecular Weight: 61,558 Da
• NCBI Official Full Name: TATA-binding protein-associated factor 2N isoform 2
• NCBI Official Synonym Full Names: TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
• NCBI Official Symbol: TAF15
• NCBI Official Synonym Symbols: Npl3; RBP56; TAF2N; TAFII68
• NCBI Protein Information: TATA-binding protein-associated factor 2N; RBP56/CSMF fusion; TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56); TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TBP-associated factor 15
• UniProt Protein Name: TATA-binding protein-associated factor 2N
• Protein Family: Transcription initiation factor
• UniProt Gene Name: TAF15
• UniProt Synonym Gene Names: RBP56; TAF2N; TAF(II)68; TAFII68
• UniProt Entry Name: RBP56_HUMAN

NCBI Description

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Description

TAF15: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; RNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 17q11.1-q11.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; nucleotide binding

Biological Process: positive regulation of transcription, DNA-dependent

Disease: Chondrosarcoma, Extraskeletal Myxoid