Neurokinin B Recombinant Protein | TAC3 recombinant protein

Neurokinin B, 17-121aa, Human, His tag, E Coli

Cat. Num. AAA203363

• Gene Names: TAC3; NKB; HH10; NKNB; PRO1155; ZNEUROK1
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: Neurokinin B; 17-121aa; Human; His tag; E Coli; ZNEuROK1; Neuromedin K; Tachykinin3; TAC3; NKB; NKNB; Gamma tachykinin 3; Neurokinin B like protein; Neurokinin B protein; Neurokinin beta; NeurokininB; NeuromedinK; Preprotachykinin B; PreprotachykininB; PRO 1155; PRO1155; TAC 3; Tachykinin 3; ZNEuROK 1.; TAC3 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH QSFGAVCKEP QEEVVPGGGR SKRDPDLYQL LQRLFKSHSS LEGLLKALSQ ASTDPKESTS PEKRDMHDFF VGLMGKRSVQ PDSPTDVNQE NVPSFGILKY PPRAE
• Sequence Length: 121

• Applicable Applications for TAC3 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for TAC3 recombinant protein

Neurokinin B, a member of the substance P-related tachykinin family, was previously known to be present in the same hypothalamic neurons as kisspeptin. This protein and its receptor are critical switches of regulator of human puberty, governed by the brain through the release of the hormone GnRH (gonadotropin-releasing hormone) which starts a series of processes that ultimately leads to the production of sex hormones. Many studies suggest new approaches to the pharmacological control of human reproduction and sex hormone-related diseases. Recombinant human Neurokinin B, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.

Product Categories/Family for TAC3 recombinant protein

Neuroscience

References

Topaloglu AK., et al. (2009). Nat Genet. 41 (3):354-8; Rance NE., et al. (2009). Peptides. 30 (1):111-22.;

NCBI and Uniprot Product Information

• NCBI GI #: 7019577
• NCBI GeneID: 6866
• NCBI Accession #: NP_037383
• NCBI GenBank Nucleotide #: NM_013251.3
• UniProt Accession #: Q9UHF0; Q6IAG2; Q71BC6; Q71BC9
• Molecular Weight: 13.8 kDa (125aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: tachykinin-3 isoform 1 preproprotein
• NCBI Official Synonym Full Names: tachykinin 3
• NCBI Official Symbol: TAC3
• NCBI Official Synonym Symbols: NKB; HH10; NKNB; PRO1155; ZNEUROK1
• NCBI Protein Information: tachykinin-3
• UniProt Protein Name: Tachykinin-3
• Protein Family: Neurokinin
• UniProt Gene Name: TAC3
• UniProt Synonym Gene Names: NKNB; NKB

NCBI Description

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Description

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (). Is a critical central regulator of gonadal function.