SYTL2 recombinant protein

Recombinant Human SYTL2 protein

Cat. Num. AAA1562578

• Gene Names: SYTL2; EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
• Purity: >90% as determined by SDS-PAGE
• Synonyms: SYTL2; Recombinant Human SYTL2 protein; Synaptotagmin-like protein 2; Breast cancer-associated antigen SGA-72M; Exophilin-4; SYTL2 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human SYTL2 (Met559-Leu880) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for SYTL2 recombinant protein

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4, 5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca2+ while binding to PIP2 is Ca2+ insensitive.

Product Categories/Family for SYTL2 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 244790013
• NCBI GeneID: 54843
• NCBI Accession #: NP_001156423.1
• NCBI GenBank Nucleotide #: NM_001162951.2
• UniProt Accession #: Q9HCH5; Q2YDA7; Q6TV07; Q6ZN59; Q6ZVC5; B3KRS3; B4DJT5; B4DKW3; B4DQ26; B7SA85; B7ZLX6; B7ZLX7
• Molecular Weight: 84,651 Da
• NCBI Official Full Name: synaptotagmin-like protein 2 isoform g
• NCBI Official Synonym Full Names: synaptotagmin like 2
• NCBI Official Symbol: SYTL2
• NCBI Official Synonym Symbols: EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
• NCBI Protein Information: synaptotagmin-like protein 2
• UniProt Protein Name: Synaptotagmin-like protein 2
• Protein Family: Synaptotagmin-like protein
• UniProt Gene Name: SYTL2
• UniProt Synonym Gene Names: KIAA1597; SGA72M; SLP2; SLP2A

NCBI Description

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]

Uniprot Description

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca2+ while binding to PIP2 is Ca2+ insensitive.