FOXP1 sirna

FOXP1 siRNA (Rat)

Cat. Num. AAA8240328

• Reactivity: Rat
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: FOXP1; FOXP1 siRNA (Rat); Forkhead box protein P1; FOXP1 sirna

• Host: Synthetic
• Reactivity: Rat
• Specificity: FOXP1 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 711

• Applicable Applications for FOXP1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat FOXP1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for FOXP1 sirna

siRNA to inhibit FOXP1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 77627729
• NCBI GeneID: 297480
• NCBI Accession #: NP_001029303.1
• NCBI GenBank Nucleotide #: NM_001034131.1
• UniProt Accession #: Q498D1
• Molecular Weight: 79,586 Da
• NCBI Official Full Name: forkhead box protein P1
• NCBI Official Synonym Full Names: forkhead box P1
• NCBI Official Symbol: Foxp1
• NCBI Protein Information: forkhead box protein P1
• UniProt Protein Name: Forkhead box protein P1
• Protein Family: Forkhead box protein
• UniProt Gene Name: Foxp1
• UniProt Entry Name: FOXP1_RAT

Uniprot Description

FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor; Cell cycle regulation

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein homodimerization activity; DNA binding; androgen receptor binding; protein heterodimerization activity; metal ion binding; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of smooth muscle cell proliferation; heart development; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; motor axon guidance; osteoclast differentiation; negative regulation of transcription from RNA polymerase II promoter; cardiac muscle cell differentiation; smooth muscle development; monocyte activation; positive regulation of mesenchymal cell proliferation; regulation of cardiac muscle cell proliferation; skeletal muscle development; immunoglobulin V(D)J recombination; in utero embryonic development; ventral spinal cord development; sarcomere organization; endothelial cell activation; regulation of transcription from RNA polymerase II promoter; regulation of monocyte differentiation; macrophage activation; pre-B cell differentiation; positive regulation of immunoglobulin production; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of tumor necrosis factor production; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of B cell apoptosis; positive regulation of epithelial cell proliferation; lung development