BMPR1A sirna

BMPR1A siRNA (Rat)

Cat. Num. AAA8217447

• Reactivity: Rat
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: BMPR1A; BMPR1A siRNA (Rat); Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; Bone morphogenetic protein 4 receptor; CD antigen CD292; BMPR1A sirna

• Host: Synthetic
• Reactivity: Rat
• Specificity: BMPR1A siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 532

• Applicable Applications for BMPR1A sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat BMPR1A gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for BMPR1A sirna

siRNA to inhibit BMPR1A expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 13540661
• NCBI GeneID: 81507
• NCBI Accession #: NP_110476.1
• NCBI GenBank Nucleotide #: NM_030849.1
• UniProt Accession #: Q78EA7; Q64308
• Molecular Weight: 59,994 Da
• NCBI Official Full Name: bone morphogenetic protein receptor type-1A
• NCBI Official Synonym Full Names: bone morphogenetic protein receptor, type IA
• NCBI Official Symbol: Bmpr1a
• NCBI Protein Information: bone morphogenetic protein receptor type-1A
• UniProt Protein Name: Bone morphogenetic protein receptor type-1A
• Protein Family: Bone morphogenetic protein receptor
• UniProt Gene Name: Bmpr1a
• UniProt Synonym Gene Names: BMP type-1A receptor; BMPR-1A; ALK-3
• UniProt Entry Name: BMR1A_RAT

NCBI Description

may act as a serine/threonine kinase receptor; may mediate bone morphogenetic protein-induced bone formation [RGD, Feb 2006]

Uniprot Description

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: EC 2.7.11.30; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Kinase, protein; TKL group; STKR family; Type1 subfamily

Cellular Component: cell soma; dendrite; plasma membrane; integral to membrane; caveola

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein homodimerization activity; metal ion binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: paraxial mesoderm development; transcription from RNA polymerase II promoter; heart morphogenesis; neural plate mediolateral pattern formation; hindlimb morphogenesis; developmental growth; neural crest cell development; positive regulation of transcription, DNA-dependent; heart development; paraxial mesoderm structural organization; mesendoderm development; dorsal/ventral axis specification; palate development; protein amino acid phosphorylation; negative regulation of neurogenesis; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of mesenchymal cell proliferation; ectoderm development; embryonic morphogenesis; cell differentiation; nervous system development; Mullerian duct regression; somitogenesis; regulation of endothelial cell proliferation; in utero embryonic development; stem cell maintenance; lateral mesoderm development; positive regulation of bone mineralization; pattern specification process; regulation of endothelial cell differentiation; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; dorsal/ventral pattern formation; mesoderm formation; pituitary gland development; cartilage development; embryonic organ development; immune response; embryonic digit morphogenesis; regulation of lateral mesodermal cell fate specification; positive regulation of epithelial cell proliferation; endoderm development; lung development