AF-1 peptide

AF-1

Cat. Num. AAA8246030

• Gene Names: IFNGR2; AF-1; IFGR2; IMD28; IFNGT1
• Purity: > 95%
• Synonyms: AF-1; AF-1 peptide

• Host: Synthetic
• Purity/Purification: > 95%
• Form/Format: Lyophilized powder
• Sequence: Lys-Asn-Glu-Phe-Ile-Arg-Phe-NH2
• Sequence Length: 337

• CAS Number: 130092-56-7
• Molecular Formula: C45H69N13O10
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Structure

Related Product Information for AF-1 peptide

Peptide to AF-1

NCBI and Uniprot Product Information

• NCBI GI #: 463552
• NCBI GeneID: 3460
• Molecular Weight: 3576.06
• NCBI Official Full Name: AF-1
• NCBI Official Synonym Full Names: interferon gamma receptor 2 (interferon gamma transducer 1)
• NCBI Official Symbol: IFNGR2
• NCBI Official Synonym Symbols: AF-1; IFGR2; IMD28; IFNGT1
• NCBI Protein Information: interferon gamma receptor 2
• UniProt Protein Name: Interferon gamma receptor 2
• UniProt Gene Name: IFNGR2
• UniProt Synonym Gene Names: IFNGT1; IFN-gamma receptor 2; IFN-gamma-R2; AF-1
• UniProt Entry Name: INGR2_HUMAN

NCBI Description

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

Uniprot Description

IFNGR2: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: cytoplasmic vesicle membrane; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; integral to plasma membrane; plasma membrane

Molecular Function: interferon-gamma receptor activity

Biological Process: cell surface receptor linked signal transduction; response to virus

Disease: Immunodeficiency 28