Diprotin A Peptide | Dpp4 peptide

Diprotin A

Cat. Num. AAA633660

• Gene Names: Dpp4; CD26; DPPIV
• Purity: Highly Purified; ~95%. Purified by HPLC.
• Synonyms: Diprotin A; Dpp4 peptide

• Host: Synthetic peptide
• Purity/Purification: Highly Purified; ~95%. Purified by HPLC.
• Form/Format: Supplied as a lyophilized powder.

• Sequence (linear): Ile-Pro-Ile
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for Dpp4 peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 56405289
• NCBI GeneID: 25253
• UniProt Accession #: P14740
• Molecular Weight: 88,089 Da
• NCBI Official Full Name: Dipeptidyl peptidase 4
• NCBI Official Synonym Full Names: dipeptidylpeptidase 4
• NCBI Official Symbol: Dpp4
• NCBI Official Synonym Symbols: CD26; DPPIV
• NCBI Protein Information: dipeptidyl peptidase 4; DPP IV; GP110 glycoprotein; dipeptidyl peptidase IV; T-cell activation antigen CD26; bile canaliculus domain-specific membrane glycoprotein
• UniProt Protein Name: Dipeptidyl peptidase 4
• Protein Family: Dipeptidyl peptidase
• UniProt Gene Name: Dpp4
• UniProt Synonym Gene Names: Cd26; DPP IV
• UniProt Entry Name: DPP4_RAT

NCBI Description

catalyzes the degradation of glucagon-like peptide-1 (Glp-1); involved in proteolysis and peptidolysis [RGD, Feb 2006]

Uniprot Description

DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily.

Protein type: Cell adhesion; Cell surface; Endoplasmic reticulum; Motility/polarity/chemotaxis; Protease; Membrane protein, integral; Vesicle; Cell cycle regulation; EC 3.4.14.5

Cellular Component: Golgi apparatus; intercellular canaliculus; focal adhesion; cell surface; membrane; lamellipodium; lysosomal membrane; endocytic vesicle; endoplasmic reticulum; apical plasma membrane; extracellular region; plasma membrane; integral to membrane; cell junction; lipid raft

Molecular Function: collagen binding; identical protein binding; protein homodimerization activity; protease binding; dipeptidyl-peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; peptide binding; receptor binding

Biological Process: regulation of cell-cell adhesion mediated by integrin; behavioral fear response; T cell activation; establishment of localization; regulation of T cell mediated immunity; T cell costimulation; positive regulation of cell proliferation; response to hypoxia; endothelial cell migration; cell adhesion; proteolysis