NIP1 Blocking Peptide | NECAB3 blocking peptide

NIP1 Blocking Peptide

Cat. Num. AAA823868

• Gene Names: NECAB3; NIP1; XB51; STIP3; EFCBP3; SYTIP2; APBA2BP; dJ63M2.4; dJ63M2.5
• Reactivity: Human, Mouse, Rat, Bovine
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: NIP1; NIP1 Blocking Peptide; APBA2BP; SYTIP2; XB51; N-terminal EF-hand calcium-binding protein 3; Amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; X11L-binding protein 51; NECAB3 blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat, Bovine
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 362

• Applicable Applications for NECAB3 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for NECAB3 blocking peptide

The peptide is used to block Anti-NIP1 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 149158725
• NCBI GeneID: 63941
• NCBI Accession #: NP_112508.3
• NCBI GenBank Nucleotide #: NM_031231.3
• UniProt Accession #: Q96P71; Q5JWF5; Q5JWF6; Q5JWF7; Q86VV1; Q9H433; Q9H8G8; Q9HBW7; Q9HCQ9; A8K780; E1P5N2
• Molecular Weight: 22,251 Da
• NCBI Official Full Name: N-terminal EF-hand calcium-binding protein 3 isoform 1
• NCBI Official Synonym Full Names: N-terminal EF-hand calcium binding protein 3
• NCBI Official Symbol: NECAB3
• NCBI Official Synonym Symbols: NIP1; XB51; STIP3; EFCBP3; SYTIP2; APBA2BP; dJ63M2.4; dJ63M2.5
• NCBI Protein Information: N-terminal EF-hand calcium-binding protein 3; X11L-binding protein 51; Nek2-interacting protein 1; EF-hand calcium binding protein 3; neuronal calcium-binding protein 3; synaptotagmin interacting protein 2; neuronal calcium-binding protein NECAB3; synaptotagmin interacting protein STIP3; amyloid beta A4 protein-binding family A member 2-binding protein; amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein
• UniProt Protein Name: N-terminal EF-hand calcium-binding protein 3
• Protein Family: N-terminal EF-hand calcium-binding protein
• UniProt Gene Name: NECAB3
• UniProt Synonym Gene Names: APBA2BP; NIP1; SYTIP2; XB51
• UniProt Entry Name: NECA3_HUMAN

NCBI Description

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

NECAB3: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: endoplasmic reticulum membrane; cytoplasm; Golgi cis cisterna; nucleus

Molecular Function: protein binding; calcium ion binding

Biological Process: regulation of amyloid precursor protein biosynthetic process; protein metabolic process; protein secretion