STAM2 sirna

STAM2 siRNA (Mouse)

Cat. Num. AAA8225396

• Gene Names: Stam2; Hbp; BB145015; 1200004O12Rik; 5730456G07Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: STAM2; STAM2 siRNA (Mouse); HBP; Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein; STAM2 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: STAM2 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 523

• Applicable Applications for STAM2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse STAM2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for STAM2 sirna

siRNA to inhibit STAM2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 9789975
• NCBI GeneID: 56324
• NCBI Accession #: NP_062641.1
• NCBI GenBank Nucleotide #: NM_019667.2
• UniProt Accession #: O88811; Q8C8Y4; A2AU00
• Molecular Weight: 46,260 Da
• NCBI Official Full Name: signal transducing adapter molecule 2
• NCBI Official Synonym Full Names: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
• NCBI Official Symbol: Stam2
• NCBI Official Synonym Symbols: Hbp; BB145015; 1200004O12Rik; 5730456G07Rik
• NCBI Protein Information: signal transducing adapter molecule 2
• UniProt Protein Name: Signal transducing adapter molecule 2
• Protein Family: Signal transducing adapter molecule
• UniProt Gene Name: Stam2
• UniProt Synonym Gene Names: Hbp; STAM-2
• UniProt Entry Name: STAM2_MOUSE

Uniprot Description

STAM2: an adaptor protein involved in the downstream signaling of cytokine receptors. Contain a SH3 domain and immunoreceptor tyrosine-based activation motif (ITAM). Acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. May modulate the signaling pathway downstream of JAK kinases upon cytokine stimulation.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; cytoplasm; endosome

Molecular Function: protein binding

Biological Process: intracellular protein transport; protein transport; transport