KCNH5 sirna

KCNH5 siRNA (Mouse)

Cat. Num. AAA8236146

• Gene Names: Kcnh5; Eag2
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: KCNH5; KCNH5 siRNA (Mouse); EAG2; Potassium voltage-gated channel subfamily H member 5; Ether-a-go-go potassium channel 2; Eag2; Voltage-gated potassium channel subunit Kv10.2; KCNH5 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: KCNH5 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 988

• Applicable Applications for KCNH5 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse KCNH5 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for KCNH5 sirna

siRNA to inhibit KCNH5 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 255522969
• NCBI GeneID: 238271
• NCBI Accession #: NP_766393.2
• NCBI GenBank Nucleotide #: NM_172805.3
• UniProt Accession #: Q920E3; Q8C035; E9QPM0
• Molecular Weight: 111,810 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily H member 5
• NCBI Official Synonym Full Names: potassium voltage-gated channel, subfamily H (eag-related), member 5
• NCBI Official Symbol: Kcnh5
• NCBI Official Synonym Symbols: Eag2
• NCBI Protein Information: potassium voltage-gated channel subfamily H member 5
• UniProt Protein Name: Potassium voltage-gated channel subfamily H member 5
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: Kcnh5
• UniProt Synonym Gene Names: Eag2; Eag2
• UniProt Entry Name: KCNH5_MOUSE

Uniprot Description

Kv10.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: voltage-gated potassium channel complex; cell surface; membrane; integral to plasma membrane; integral to membrane; intracellular

Molecular Function: calmodulin binding; voltage-gated potassium channel activity; signal transducer activity; potassium channel activity; protein heterodimerization activity; ion channel activity; voltage-gated ion channel activity; two-component sensor activity

Biological Process: regulation of membrane potential; transport; regulation of G2/M transition of mitotic cell cycle; two-component signal transduction system (phosphorelay); ion transport; signal transduction; transmembrane transport; potassium ion transport