IFNGR1 sirna

IFNGR1 siRNA (Mouse)

Cat. Num. AAA8230155

• Gene Names: Ifngr1; Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: IFNGR1; IFNGR1 siRNA (Mouse); IFNGR; Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CD antigen CD119; IFNGR1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: IFNGR1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 477

• Applicable Applications for IFNGR1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse IFNGR1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for IFNGR1 sirna

siRNA to inhibit IFNGR1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 6754306
• NCBI GeneID: 15979
• NCBI Accession #: NP_034641.1
• NCBI GenBank Nucleotide #: NM_010511.2
• UniProt Accession #: P15261; Q91Y85
• Molecular Weight: 52,343 Da
• NCBI Official Full Name: interferon gamma receptor 1
• NCBI Official Synonym Full Names: interferon gamma receptor 1
• NCBI Official Symbol: Ifngr1
• NCBI Official Synonym Symbols: Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
• NCBI Protein Information: interferon gamma receptor 1
• UniProt Protein Name: Interferon gamma receptor 1
• Protein Family: Interferon gamma receptor
• UniProt Gene Name: Ifngr1
• UniProt Synonym Gene Names: Ifngr; IFN-gamma receptor 1; IFN-gamma-R1
• UniProt Entry Name: INGR1_MOUSE

Uniprot Description

IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: membrane; endoplasmic reticulum; dendrite; postsynaptic density; integral to membrane; plasma membrane; vesicle

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; cytokine binding

Biological Process: cytokine and chemokine mediated signaling pathway