GGPS1 sirna

GGPS1 siRNA (Mouse)

Cat. Num. AAA8210699

• Gene Names: Ggps1; C79210; AI843169; 1810026C22Rik; 9530089B04Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: GGPS1; GGPS1 siRNA (Mouse); Geranylgeranyl pyrophosphate synthase; GGPP synthase; GGPPSase; 2E.6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; GGPS1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: GGPS1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 300

• Applicable Applications for GGPS1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse GGPS1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for GGPS1 sirna

siRNA to inhibit GGPS1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 6806915
• NCBI GeneID: 14593
• NCBI Accession #: NP_034412.1
• NCBI GenBank Nucleotide #: NM_010282.2
• UniProt Accession #: Q9WTN0
• Molecular Weight: 34,707 Da
• NCBI Official Full Name: geranylgeranyl pyrophosphate synthase
• NCBI Official Synonym Full Names: geranylgeranyl diphosphate synthase 1
• NCBI Official Symbol: Ggps1
• NCBI Official Synonym Symbols: C79210; AI843169; 1810026C22Rik; 9530089B04Rik
• NCBI Protein Information: geranylgeranyl pyrophosphate synthase
• UniProt Protein Name: Geranylgeranyl pyrophosphate synthase
• UniProt Gene Name: Ggps1
• UniProt Synonym Gene Names: GGPP synthase; GGPPSase
• UniProt Entry Name: GGPPS_MOUSE

Uniprot Description

GGPS1: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Belongs to the FPP/GGPP synthase family.

Protein type: Motility/polarity/chemotaxis; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.10; EC 2.5.1.29; EC 2.5.1.1; Transferase

Cellular Component: cytoplasm

Molecular Function: dimethylallyltranstransferase activity; metal ion binding; protoheme IX farnesyltransferase activity; trans-pentaprenyltranstransferase activity; 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity; 4-hydroxybenzoate octaprenyltransferase activity; protein prenyltransferase activity; transferase activity; geranyltranstransferase activity; farnesyltranstransferase activity; protein geranylgeranyltransferase activity; (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity; prenyltransferase activity

Biological Process: isoprenoid metabolic process; isoprenoid biosynthetic process