IL-31RA Blocking Peptide | IL31RA blocking peptide

IL-31RA Blocking Peptide

Cat. Num. AAA824225

• Gene Names: IL31RA; CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384
• Reactivity: Human
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: IL-31RA; IL-31RA Blocking Peptide; CRL3; GPL; Interleukin-31 receptor subunit alpha; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; Cytokine receptor-like 3; GLM-R; hGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; ZcytoR17; IL31RA blocking peptide

• Host: Synthetic
• Reactivity: Human
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 745

• Applicable Applications for IL31RA blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4°C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shpping:Blue Ice; Store at -20°C for one year.

Related Product Information for IL31RA blocking peptide

The peptide is used to block Anti-IL-31RA Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 336391156
• NCBI GeneID: 133396
• NCBI Accession #: NP_001229565.1
• NCBI GenBank Nucleotide #: NM_001242636.1
• UniProt Accession #: P78324; Q2TBA1; Q6EBC3; Q6EBC4; Q6EBC5; Q6EBC6; Q6UWL8; Q8WYJ0; A6NIF8; Q8NI17
• NCBI Official Full Name: interleukin-31 receptor subunit alpha isoform 2
• NCBI Official Synonym Full Names: interleukin 31 receptor A
• NCBI Official Symbol: IL31RA
• NCBI Official Synonym Symbols: CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384
• NCBI Protein Information: interleukin-31 receptor subunit alpha; zcytoR17; IL-31R subunit alpha; cytokine receptor-like 3; class I cytokine receptor; IL-31 receptor subunit alpha; gp130-like monocyte receptor; soluble type I cytokine receptor CRL3
• UniProt Protein Name: Interleukin-31 receptor subunit alpha
• Protein Family: Interleukin-31 receptor
• UniProt Gene Name: IL31RA
• UniProt Synonym Gene Names: CRL3; GPL; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; hGLM-R; Gp130-like receptor
• UniProt Entry Name: IL31R_HUMAN

NCBI Description

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Uniprot Description

IL31RA: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Defects in IL31RA are the cause of amyloidosis primary localized cutaneous type 2 (PLCA2). PLCA2 is primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; cytokine binding; transcription coactivator activity; protein kinase binding

Biological Process: macrophage differentiation; monocyte differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; MAPKKK cascade; defense response; JAK-STAT cascade; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; homeostatic process; positive regulation of cell proliferation; negative regulation of macrophage activation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis

Disease: Amyloidosis, Primary Localized Cutaneous, 2