SOX11 sirna

SOX11 siRNA (Human)

Cat. Num. AAA8239806

• Gene Names: SOX11; MRD27
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SOX11; SOX11 siRNA (Human); Transcription factor SOX-11; SOX11 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SOX11 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 441

• Applicable Applications for SOX11 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SOX11 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SOX11 sirna

siRNA to inhibit SOX11 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 4507161
• NCBI GeneID: 6664
• NCBI Accession #: NP_003099.1
• NCBI GenBank Nucleotide #: NM_003108.3
• UniProt Accession #: P35716; Q4ZFV8
• Molecular Weight: 46,679 Da
• NCBI Official Full Name: transcription factor SOX-11
• NCBI Official Synonym Full Names: SRY (sex determining region Y)-box 11
• NCBI Official Symbol: SOX11
• NCBI Official Synonym Symbols: MRD27
• NCBI Protein Information: transcription factor SOX-11
• UniProt Protein Name: Transcription factor SOX-11
• Protein Family: Transcription factor
• UniProt Gene Name: SOX11
• UniProt Entry Name: SOX11_HUMAN

NCBI Description

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

SOX11: Probably important in the developing nervous system. May also have a role in tissue modeling during development.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: cytoplasm; nucleus

Molecular Function: translation factor activity, nucleic acid binding; transcription factor activity

Biological Process: neural crest cell development; translation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of lymphocyte proliferation; glial cell proliferation; neuron differentiation; sympathetic nervous system development; regulation of transforming growth factor beta receptor signaling pathway; embryonic digestive tract morphogenesis; positive regulation of cell proliferation; hard palate development; kidney development; oligodendrocyte development; skeletal development; positive regulation of BMP signaling pathway; glial cell development; positive regulation of neurogenesis; transcription, DNA-dependent; positive regulation of hormone secretion; positive regulation of ossification; embryonic skeletal morphogenesis; positive regulation of osteoblast differentiation; limb bud formation; spinal cord development; positive regulation of transcription from RNA polymerase II promoter; lens morphogenesis in camera-type eye; soft palate development; neural tube formation; positive regulation of neuron differentiation

Disease: Mental Retardation, Autosomal Dominant 27