SBF2 sirna
SBF2 siRNA (Human)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. [provided by RefSeq, Jul 2008]
Uniprot Description
MTMR13: a widely expressed pseudophosphatase and peripheral membrane guanine nucleotide exchange factor (GEF) that activates RAB28, a small G protein of the Rab subfamily. Promotes Rab21 GTPase activation associated with PI(3)P endosomes. Coordinates PIP3 and Rab21 regulation in an endosomal pathway. Functions together with Mtm and Rab21, along with Rab11-mediated endosomal trafficking, to control macrophage protrusion formation and to promote turnover of a PI(3)P subpool essential for endosomal trafficking. Interacts with MTMR2. Defects in MTMR13 are the cause of Charcot-Marie-Tooth disease type 4B2 (CMT4B2). CMT4B2 is a recessive form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Two isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rab; GEFs
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: membrane; vacuolar membrane
Molecular Function: protein binding; protein homodimerization activity; phosphatase regulator activity; phosphoric monoester hydrolase activity; Rab guanyl-nucleotide exchange factor activity; phosphoinositide binding; phosphatase binding
Biological Process: myelination; dephosphorylation; protein tetramerization
Disease: Charcot-marie-tooth Disease, Type 4b2
Research Articles on SBF2
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Product Notes
The SBF2 sbf2 (Catalog #AAA8240902) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The SBF2 siRNA (Human) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SBF2 can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the SBF2 sbf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SBF2, siRNA" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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