SASH3 sirna

SASH3 siRNA (Human)

Cat. Num. AAA8219396

• Gene Names: SASH3; SLY; 753P9; HACS2; CXorf9; SH3D6C
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SASH3; SASH3 siRNA (Human); CXorf9; SLY; SAM and SH3 domain-containing protein 3; SH3 protein expressed in lymphocytes homolog; SASH3 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SASH3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 380

• Applicable Applications for SASH3 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SASH3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SASH3 sirna

siRNA to inhibit SASH3 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 9506363
• NCBI GeneID: 54440
• NCBI Accession #: NP_061863.1
• NCBI GenBank Nucleotide #: NM_018990.3
• UniProt Accession #: O75995; Q5JZ38; A6NCH1; A8K7K8
• Molecular Weight: 41,595 Da
• NCBI Official Full Name: SAM and SH3 domain-containing protein 3
• NCBI Official Synonym Full Names: SAM and SH3 domain containing 3
• NCBI Official Symbol: SASH3
• NCBI Official Synonym Symbols: SLY; 753P9; HACS2; CXorf9; SH3D6C
• NCBI Protein Information: SAM and SH3 domain-containing protein 3
• UniProt Protein Name: SAM and SH3 domain-containing protein 3
• Protein Family: SAM and SH3 domain-containing protein
• UniProt Gene Name: SASH3
• UniProt Synonym Gene Names: CXorf9; SLY
• UniProt Entry Name: SASH3_HUMAN

NCBI Description

The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.[provided by RefSeq, Sep 2009]

Uniprot Description

SLY: May function as a signaling adapter protein in lymphocytes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq26

Cellular Component: cytoplasm; nucleus

Biological Process: positive regulation of interleukin-4 production; positive regulation of immunoglobulin production; positive regulation of interferon-gamma production; homeostasis of number of cells within a tissue; positive regulation of B cell proliferation; positive regulation of interleukin-2 production; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of tumor necrosis factor production; positive regulation of organ growth; positive regulation of interleukin-10 production