RBMXL1 sirna

RBMXL1 siRNA (Human)

Cat. Num. AAA8215409

• Gene Names: RBMXL1; RBM1
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: RBMXL1; RBMXL1 siRNA (Human); RNA binding motif protein. X-linked-like-1; Heterogeneous nuclear ribonucleoprotein G-like 1; RBMXL1 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: RBMXL1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 390

• Applicable Applications for RBMXL1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human RBMXL1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for RBMXL1 sirna

siRNA to inhibit RBMXL1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 242117971
• NCBI GeneID: 494115
• NCBI Accession #: NP_001156008.1
• NCBI GenBank Nucleotide #: NM_001162536.2
• UniProt Accession #: Q96E39
• Molecular Weight: 42,142 Da
• NCBI Official Full Name: RNA binding motif protein, X-linked-like-1
• NCBI Official Synonym Full Names: RNA binding motif protein, X-linked-like 1
• NCBI Official Symbol: RBMXL1
• NCBI Official Synonym Symbols: RBM1
• NCBI Protein Information: RNA binding motif protein, X-linked-like-1
• UniProt Protein Name: RNA binding motif protein, X-linked-like-1
• Protein Family: RNA binding motif protein
• UniProt Gene Name: RBMXL1
• UniProt Entry Name: RMXL1_HUMAN

NCBI Description

This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. The preservation of the ORF by purifying selection in all Old World monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure with the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternative splicing results in two transcript variants. [provided by RefSeq, Jun 2009]

Uniprot Description

RBMXL1: RNA-binding protein which may be involved in pre-mRNA splicing.

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: spliceosome

Molecular Function: single-stranded RNA binding; nucleotide binding

Biological Process: mRNA splice site selection; positive regulation of transcription, DNA-dependent