IL20RA sirna

IL20RA siRNA (Human)

Cat. Num. AAA8214326

• Gene Names: IL20RA; CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: IL20RA; IL20RA siRNA (Human); Interleukin-20 receptor subunit alpha; IL-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; Cytokine receptor class-II member 8; Cytokine receptor family 2 member 8; CRF2-8; IL-20R1; ZcytoR7; IL20RA sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: IL20RA siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 504

• Applicable Applications for IL20RA sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human IL20RA gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for IL20RA sirna

siRNA to inhibit IL20RA expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 524590437
• NCBI GeneID: 53832
• NCBI Accession #: NP_001265651.1
• NCBI GenBank Nucleotide #: NM_001278722.1
• UniProt Accession #: Q9UHF4; Q14CW2; Q6UWA9; Q96SH8; B4DLR5; F5H675
• Molecular Weight: 57,366 Da
• NCBI Official Full Name: interleukin-20 receptor subunit alpha isoform 2
• NCBI Official Synonym Full Names: interleukin 20 receptor, alpha
• NCBI Official Symbol: IL20RA
• NCBI Official Synonym Symbols: CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha
• NCBI Protein Information: interleukin-20 receptor subunit alpha
• UniProt Protein Name: Interleukin-20 receptor subunit alpha
• Protein Family: Interleukin-20 receptor
• UniProt Gene Name: IL20RA
• UniProt Synonym Gene Names: IL-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; CRF2-8
• UniProt Entry Name: I20RA_HUMAN

NCBI Description

This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

IL20RA: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. Belongs to the type II cytokine receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-20 binding

Biological Process: regulation of bone resorption; cytokine and chemokine mediated signaling pathway