FOXP2 sirna

FOXP2 siRNA (Human)

Cat. Num. AAA8216107

• Gene Names: FOXP2; SPCH1; CAGH44; TNRC10
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: FOXP2; FOXP2 siRNA (Human); CAGH44; TNRC10; Forkhead box protein P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein; FOXP2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: FOXP2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 732

• Applicable Applications for FOXP2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human FOXP2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for FOXP2 sirna

siRNA to inhibit FOXP2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 289666732
• NCBI GeneID: 93986
• NCBI Accession #: NP_001166237.1
• NCBI GenBank Nucleotide #: NM_001172766.2
• UniProt Accession #: O15409; Q6ZND1; Q75MJ3; Q8IZE0; Q8N0W2; Q8N6B7; Q8N6B8; Q8NFQ1; A0AUV6; A4D0U8; A6NNW4; B4DLD9
• Molecular Weight: 81,840 Da
• NCBI Official Full Name: forkhead box protein P2 isoform V
• NCBI Official Synonym Full Names: forkhead box P2
• NCBI Official Symbol: FOXP2
• NCBI Official Synonym Symbols: SPCH1; CAGH44; TNRC10
• NCBI Protein Information: forkhead box protein P2
• UniProt Protein Name: Forkhead box protein P2
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXP2
• UniProt Synonym Gene Names: CAGH44; TNRC10
• UniProt Entry Name: FOXP2_HUMAN

NCBI Description

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Uniprot Description

FOXP2: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; transcription factor activity

Biological Process: caudate nucleus development; skeletal muscle development; camera-type eye development; transcription, DNA-dependent; righting reflex; putamen development; negative regulation of transcription from RNA polymerase II promoter; vocal learning; post-embryonic development; smooth muscle development; positive regulation of mesenchymal cell proliferation; cerebellum development; cerebral cortex development; negative regulation of transcription, DNA-dependent; alveolus development; growth

Disease: Speech-language Disorder 1