DSCR3 sirna

DSCR3 siRNA (Human)

Cat. Num. AAA828193

• Gene Names: DSCR3; DCRA; DSCRA
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: DSCR3; DSCR3 siRNA (Human); DCRA; DSCRA; Down syndrome critical region protein 3; Down syndrome critical region protein A; DSCR3 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: DSCR3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 297

• Applicable Applications for DSCR3 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human DSCR3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for DSCR3 sirna

siRNA to inhibit DSCR3 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 5174425
• NCBI GeneID: 10311
• NCBI Accession #: NP_006043.1
• NCBI GenBank Nucleotide #: NM_006052.1
• UniProt Accession #: O14972; Q2TAY6; B2R6T8; B7Z6B1; D3DSH4
• Molecular Weight: 29,885 Da
• NCBI Official Full Name: Down syndrome critical region protein 3
• NCBI Official Synonym Full Names: Down syndrome critical region 3
• NCBI Official Symbol: DSCR3
• NCBI Official Synonym Symbols: DCRA; DSCRA
• NCBI Protein Information: Down syndrome critical region protein 3
• UniProt Protein Name: Down syndrome critical region protein 3
• Protein Family: Down syndrome critical region protein
• UniProt Gene Name: DSCR3
• UniProt Synonym Gene Names: DCRA; DSCRA
• UniProt Entry Name: DSCR3_HUMAN

NCBI Description

The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined. [provided by RefSeq, Jul 2008]

Uniprot Description

DSCR3: The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined. [provided by RefSeq, Jul 2008]

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: nucleus; endosome

Molecular Function: protein transporter activity

Biological Process: intracellular protein transport