APPBP2 sirna

APPBP2 siRNA (Human)

Cat. Num. AAA8216916

• Gene Names: APPBP2; PAT1; APP-BP2; HS.84084
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: APPBP2; APPBP2 siRNA (Human); KIAA0228; PAT1; Amyloid protein-binding protein 2; Amyloid beta precursor protein-binding protein 2; APP-BP2; Protein interacting with APP tail 1; APPBP2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: APPBP2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 585

• Applicable Applications for APPBP2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human APPBP2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for APPBP2 sirna

siRNA to inhibit APPBP2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 541862246
• NCBI GeneID: 10513
• NCBI Accession #: NP_001269405.1
• NCBI GenBank Nucleotide #: NM_001282476.1
• UniProt Accession #: Q92624; O95095; Q8WVC9; A8K862
• Molecular Weight: 66,853 Da
• NCBI Official Full Name: amyloid protein-binding protein 2 isoform 2
• NCBI Official Synonym Full Names: amyloid beta precursor protein (cytoplasmic tail) binding protein 2
• NCBI Official Symbol: APPBP2
• NCBI Official Synonym Symbols: PAT1; APP-BP2; HS.84084
• NCBI Protein Information: amyloid protein-binding protein 2
• UniProt Protein Name: Amyloid protein-binding protein 2
• Protein Family: Amyloid protein-binding protein
• UniProt Gene Name: APPBP2
• UniProt Synonym Gene Names: KIAA0228; PAT1; APP-BP2
• UniProt Entry Name: APBP2_HUMAN

NCBI Description

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

APPBP2: May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: microtubule; microtubule associated complex; cytoplasmic vesicle membrane; cytoplasm; nucleus

Molecular Function: protein binding; microtubule motor activity

Biological Process: intracellular protein transport; intracellular transport; metabolic process